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Overexpression of an Immune Checkpoint (CD155) in Breast Cancer Associated with Prognostic Significance and Exhausted Tumor-Infiltrating Lymphocytes: A Cohort Study

التفاصيل البيبلوغرافية
العنوان: Overexpression of an Immune Checkpoint (CD155) in Breast Cancer Associated with Prognostic Significance and Exhausted Tumor-Infiltrating Lymphocytes: A Cohort Study
المؤلفون: Yu-Chen Li, Quan Zhou, Qing-Kun Song, Rui-Bin Wang, Shuzhen Lyu, Xiudong Guan, Yan-Jie Zhao, Jiang-Ping Wu
المصدر: Journal of Immunology Research, Vol 2020 (2020)
بيانات النشر: Hindawi Limited, 2020.
سنة النشر: 2020
المجموعة: LCC:Immunologic diseases. Allergy
مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607
الوصف: Purpose. The immune checkpoint inhibitor is approved for breast cancer treatment, but the low expression of PD-L1 limits the immunotherapy. CD155 is another immune checkpoint protein in cancers and interacts with ligands to regulate immune microenvironment. This study is aimed at investigating the expression of CD155 and the association with prognosis and pathological features of breast cancer. Methods. 126 patients were recruited this cohort study consecutively, and CD155 expression on tumor cells was detected by immunohistochemistry. The Kaplan-Meier survival curve and Cox hazard regression model were used to estimate the association. Results. 38.1% patients had an overexpression of CD155, and the proportion of tumor cells with CD155 overexpression was 17%, 39%, 37%, and 62% among Luminal A, Luminal B, HER2-positive, and triple negative breast cancer cases, respectively (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2314-8861
2314-7156
Relation: https://doaj.org/toc/2314-8861; https://doaj.org/toc/2314-7156
DOI: 10.1155/2020/3948928
URL الوصول: https://doaj.org/article/7d76ae06e9634497a44c02ee22850421
رقم الانضمام: edsdoj.7d76ae06e9634497a44c02ee22850421
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23148861
23147156
DOI:10.1155/2020/3948928