Academic Journal
Evaluation of oxidative stress and genetic instability among residents near mobile phone base stations in Germany
| العنوان: | Evaluation of oxidative stress and genetic instability among residents near mobile phone base stations in Germany |
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| المؤلفون: | Sachin Gulati, Wilhelm Mosgoeller, Dietrich Moldan, Pavol Kosik, Matus Durdik, Lukas Jakl, Milan Skorvaga, Eva Markova, Dominika Kochanova, Katarina Vigasova, Igor Belyaev |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 279, Iss , Pp 116486- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | Radiofrequency electromagnetic fields, RF-EMF, Low dose chronic exposure, Genetic instability, Oxidative stress, DNA damage, Chromosomal aberrations, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Human exposure to radiofrequency electromagnetic fields (RF-EMF) is restricted to prevent thermal effects in the tissue. However, at very low intensity exposure ''non-thermal'' biological effects, like oxidative stress, DNA or chromosomal aberrations, etc. collectively termed genomic-instability can occur after few hours. Little is known about chronic (years long) exposure with non-thermal RF-EMF.We identified two neighboring housing estates in a rural region with residents exposed to either relatively low (control-group) or relatively high (exposed-group) RF-EMF emitted from nearby mobile phone base stations (MPBS). 24 healthy adults that lived in their homes at least for 5 years volunteered. The homes were surveyed for common types of EMF, blood samples were tested for oxidative status, transient DNA alterations, permanent chromosomal damage, and specific cancer related genetic markers, like MLL gene rearrangements. We documented possible confounders, like age, sex, nutrition, life-exposure to ionizing radiation (X-rays), occupational exposures, etc.The groups matched well, age, sex, lifestyle and occupational risk factors were similar. The years long exposure had no measurable effect on MLL gene rearrangements and c-Abl-gene transcription modification. Associated with higher exposure, we found higher levels of lipid oxidation and oxidative DNA-lesions, though not statistically significant. DNA double strand breaks, micronuclei, ring chromosomes, and acentric chromosomes were not significantly different between the groups. Chromosomal aberrations like dicentric chromosomes (p=0.007), chromatid gaps (p=0.019), chromosomal fragments (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651324005621; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2024.116486 |
| URL الوصول: | https://doaj.org/article/7d6a1f4997f3423e9442ba4cd7417570 |
| رقم الانضمام: | edsdoj.7d6a1f4997f3423e9442ba4cd7417570 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2024.116486 |