Academic Journal
A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS
| العنوان: | A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS |
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| المؤلفون: | Brandon Mark, Sen-Lin Lai, Aref Arzan Zarin, Laurina Manning, Heather Q Pollington, Ashok Litwin-Kumar, Albert Cardona, James W Truman, Chris Q Doe |
| المصدر: | eLife, Vol 10 (2021) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | neuroblast, hemilineage, temporal identity, cell lineage, neural circuit, Notch, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The mechanisms specifying neuronal diversity are well characterized, yet it remains unclear how or if these mechanisms regulate neural circuit assembly. To address this, we mapped the developmental origin of 160 interneurons from seven bilateral neural progenitors (neuroblasts) and identify them in a synapse-scale TEM reconstruction of the Drosophila larval central nervous system. We find that lineages concurrently build the sensory and motor neuropils by generating sensory and motor hemilineages in a Notch-dependent manner. Neurons in a hemilineage share common synaptic targeting within the neuropil, which is further refined based on neuronal temporal identity. Connectome analysis shows that hemilineage-temporal cohorts share common connectivity. Finally, we show that proximity alone cannot explain the observed connectivity structure, suggesting hemilineage/temporal identity confers an added layer of specificity. Thus, we demonstrate that the mechanisms specifying neuronal diversity also govern circuit formation and function, and that these principles are broadly applicable throughout the nervous system. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/67510; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.67510 |
| URL الوصول: | https://doaj.org/article/7c643a9dcfe149a986542c2158e46cb8 |
| رقم الانضمام: | edsdoj.7c643a9dcfe149a986542c2158e46cb8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.67510 |