التفاصيل البيبلوغرافية
| العنوان: |
Mosaic ablation of pancreatic β cells induces de-differentiation and repetitive proliferation of residual β cells in adult mice |
| المؤلفون: |
Ryo Hatano, Xilin Zhang, Eunyoung Lee, Atsushi Kaneda, Tomoaki Tanaka, Takashi Miki |
| المصدر: |
iScience, Vol 27, Iss 9, Pp 110656- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Physiology, Molecular biology, Cell biology, Science |
| الوصف: |
Summary: Diabetes mellitus is induced by quantitative and qualitative decline in pancreatic β cells. Although its radical therapy has not yet been established, β cell regeneration is a promising option. We investigate here two mouse models of β cell regeneration induced after ∼80% reduction in β cell number: Cre/loxP-mediated β cell ablation and partial pancreatectomy. Cre/loxP-mediated, mosaic-pattern of β cell ablation by diphtheria toxin (DT) prompted rapid β cell replenishment through repeated proliferation of rare, highly proliferative DT receptor-negative β cells along with increase in Hes1, Neurog3, Ascl1, and Aldh1a3 (immature/dedifferentiated β cell markers) and decrease in Mafa (a mature β cell marker) in the islets. In contrast, pancreatectomy also prompted active proliferation, but with no change in these immature/dedifferentiated or mature β cell markers. Our findings demonstrate that the mode of β cell regeneration differs between Cre/loxP-mediated β cell ablation and surgical β cell reduction, and the former involves β cell dedifferentiation followed by active repetitive cell proliferation of a small population of β cells. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004224018819; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2024.110656 |
| URL الوصول: |
https://doaj.org/article/7c38aa3bc583471abb24767acbe8419f |
| رقم الانضمام: |
edsdoj.7c38aa3bc583471abb24767acbe8419f |
| قاعدة البيانات: |
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