Academic Journal
Glycosylphosphatidylinositol-anchored proteins as chaperones and co-receptors for FERONIA receptor kinase signaling in Arabidopsis
| العنوان: | Glycosylphosphatidylinositol-anchored proteins as chaperones and co-receptors for FERONIA receptor kinase signaling in Arabidopsis |
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| المؤلفون: | Chao Li, Fang-Ling Yeh, Alice Y Cheung, Qiaohong Duan, Daniel Kita, Ming-Che Liu, Jacob Maman, Emily J Luu, Brendan W Wu, Laura Gates, Methun Jalal, Amy Kwong, Hunter Carpenter, Hen-Ming Wu |
| المصدر: | eLife, Vol 4 (2015) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | malectin domain-containing receptor kinase, FERONIA as coreceptor, receptor kinase and GPI-AP as functional partner, plant Rho GTPase signaling, RALF, LORELEI/LLG1 as coreceptor, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The Arabidopsis receptor kinase FERONIA (FER) is a multifunctional regulator for plant growth and reproduction. Here we report that the female gametophyte-expressed glycosylphosphatidylinositol-anchored protein (GPI-AP) LORELEI and the seedling-expressed LRE-like GPI-AP1 (LLG1) bind to the extracellular juxtamembrane region of FER and show that this interaction is pivotal for FER function. LLG1 interacts with FER in the endoplasmic reticulum and on the cell surface, and loss of LLG1 function induces cytoplasmic retention of FER, consistent with transport of FER from the endoplasmic reticulum to the plasma membrane in a complex with LLG1. We further demonstrate that LLG1 is a component of the FER-regulated RHO GTPase signaling complex and that fer and llg1 mutants display indistinguishable growth, developmental and signaling phenotypes, analogous to how lre and fer share similar reproductive defects. Together our results support LLG1/LRE acting as a chaperone and co-receptor for FER and elucidate a mechanism by which GPI-APs enable the signaling capacity of a cell surface receptor. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/06587; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.06587 |
| URL الوصول: | https://doaj.org/article/7c0af066ef0e4d6482463303e4e8a905 |
| رقم الانضمام: | edsdoj.7c0af066ef0e4d6482463303e4e8a905 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.06587 |