Academic Journal
DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells.
| العنوان: | DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells. |
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| المؤلفون: | Shinichi Hashimoto, Takayoshi Shirasaki, Taro Yamashita, Sadahiro Iwabuchi, Yutaka Suzuki, Yuzuru Takamura, Yoshiaki Ukita, Shungo Deshimaru, Toshitugu Okayama, Kazuho Ikeo, Kazuyuki Kuroki, Kazunori Kawaguchi, Eishiro Mizukoshi, Kouji Matsushima, Masao Honda, Shuichi Kaneko |
| المصدر: | PLoS ONE, Vol 16, Iss 2, p e0246313 (2021) |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Human hepatitis B virus (HBV) infection remains a serious health problem worldwide. However, the mechanism for the maintenance of HBV in a latent state within host cells remains unclear. Here, using single-cell RNA sequencing analysis, we identified four genes linked to the maintenance of HBV in a liver cell line expressing HBV RNA at a low frequency. These genes included DOCK11 and DENND2A, which encode small GTPase regulators. In primary human hepatocytes infected with HBV, knockdown of these two genes decreased the amount of both HBV DNA and covalently closed circular DNA to below the limit of detection. Our findings reveal a role for DOCK11 and DENND2A in the maintenance of HBV. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0246313 |
| URL الوصول: | https://doaj.org/article/a7be39574d3b48dbb1205d50da5a0ce5 |
| رقم الانضمام: | edsdoj.7be39574d3b48dbb1205d50da5a0ce5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0246313 |