Academic Journal
Bosentan: A considerable increase in the survival of patients with pulmonary hypertension associated with systemic rheumatic diseases
| العنوان: | Bosentan: A considerable increase in the survival of patients with pulmonary hypertension associated with systemic rheumatic diseases |
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| المؤلفون: | A V Volkov, N N Iudkina, E V Nikolaeva, I A Kurmukov, S I Glukhova, E L Nasonov |
| المصدر: | Терапевтический архив, Vol 86, Iss 5, Pp 32-39 (2014) |
| بيانات النشر: | "Consilium Medicum" Publishing house, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | scleroderma systematica, pulmonary hypertension, bosentan, survival, right heart catheterization, Medicine |
| الوصف: | AIM: To evaluate the short-term efficacy of the nonselective endothelin receptor antagonist bosentan in the treatment of pulmonary hypertension (PH) associated with diffuse connective tissue diseases (CTD), as well as its effect on survival in both monotherapy and in combination with other PH-specific agents/MATERIAL AND METHODS: The study included 20 CDT-associated PH patients who had been hospitalized in 2009-2013. All the patients had valid diagnoses of scleroderma systematica (SDS) (n=18) or systemic lupus erythematosus (SLE) (n=2). Bosentan was given in an initial dose of 62.5 mg/day twice for 4 weeks, then 125 mg/day twice/RESULTS: Eighteen patents completed therapy at 16 weeks. One patient with Functional Class (FC) IV PH associated with SDS died after 10 weeks of treatment because of PH progression; bosentan was discontinued in another patient following 4 weeks because of the enhanced activity of transaminases. The patients who had completed the investigation showed a significant FC decrease (from 2.9±1.0 to 2.4±1.0 following 16 weeks; р=0.03), an increase in 6-minute walking distance (from 298±140 to 375±94 m; р |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 0040-3660 2309-5342 |
| Relation: | https://ter-arkhiv.ru/0040-3660/article/view/31477; https://doaj.org/toc/0040-3660; https://doaj.org/toc/2309-5342 |
| URL الوصول: | https://doaj.org/article/a7b182bd00b044f0aff9c6a5d2c4a27e |
| رقم الانضمام: | edsdoj.7b182bd00b044f0aff9c6a5d2c4a27e |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 00403660 23095342 |
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