التفاصيل البيبلوغرافية
| العنوان: |
Characteristics of Staphylococcus aureus Isolated from Patients in Busia County Referral Hospital, Kenya |
| المؤلفون: |
Benear Apollo Obanda, Elizabeth A. J. Cook, Eric M. Fèvre, Lilly Bebora, William Ogara, Shu-Hua Wang, Wondwossen Gebreyes, Ronald Ngetich, Dolphine Wandede, Johnstone Muyodi, Beth Blane, Francesc Coll, Ewan M. Harrison, Sharon J. Peacock, George C. Gitao |
| المصدر: |
Pathogens, Vol 11, Iss 12, p 1504 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
S. aureus, MSSA, MRSA, hospital, Kenya, antimicrobial resistance, Medicine |
| الوصف: |
Staphylococcus aureus is an important pathogen associated with hospital, community, and livestock-acquired infections, with the ability to develop resistance to antibiotics. Nasal carriage by hospital inpatients is a risk for opportunistic infections. Antibiotic susceptibility patterns, virulence genes and genetic population structure of S. aureus nasal isolates, from inpatients at Busia County Referral Hospital (BCRH) were analyzed. A total of 263 inpatients were randomly sampled, from May to July 2015. The majority of inpatients (85.9%) were treated empirically with antimicrobials, including ceftriaxone (65.8%) and metronidazole (49.8%). Thirty S. aureus isolates were cultured from 29 inpatients with a prevalence of 11% (10.3% methicillin-susceptible S. aureus (MSSA), 0.8% methicillin resistant S. aureus (MRSA)). Phenotypic and genotypic resistance was highest to penicillin-G (96.8%), trimethoprim (73.3%), and tetracycline (13.3%) with 20% of isolates classified as multidrug resistant. Virulence genes, Panton-Valentine leukocidin (pvl), toxic shock syndrome toxin-1 (tsst-1), and sasX gene were detected in 16.7%, 23.3% and 3.3% of isolates. Phylogenetic analysis showed 4 predominant clonal complexes CC152, CC8, CC80, and CC508. This study has identified that inpatients of BCRH were carriers of S. aureus harbouring virulence genes and resistance to a range of antibiotics. This may indicate a public health risk to other patients and the community. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-0817 |
| Relation: |
https://www.mdpi.com/2076-0817/11/12/1504; https://doaj.org/toc/2076-0817 |
| DOI: |
10.3390/pathogens11121504 |
| URL الوصول: |
https://doaj.org/article/7a046319fc014d90bba3d4f3c1ec7169 |
| رقم الانضمام: |
edsdoj.7a046319fc014d90bba3d4f3c1ec7169 |
| قاعدة البيانات: |
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