التفاصيل البيبلوغرافية
| العنوان: |
A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites |
| المؤلفون: |
Stefan Reich, Chi D. L. Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B. Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach |
| المصدر: |
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| بيانات النشر: |
Nature Portfolio, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabolism and concomitant resistance to folate-based therapeutics. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-16747-y |
| URL الوصول: |
https://doaj.org/article/79d8f5e4871145f68820d3fe6d215985 |
| رقم الانضمام: |
edsdoj.79d8f5e4871145f68820d3fe6d215985 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder