Academic Journal
The prognostic importance of the angiotensin II/angiotensin-(1–7) ratio in patients with SARS-CoV-2 infection
| العنوان: | The prognostic importance of the angiotensin II/angiotensin-(1–7) ratio in patients with SARS-CoV-2 infection |
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| المؤلفون: | Luis M Amezcua-Guerra, Leonardo del Valle, Héctor González-Pacheco, Rashidi Springall, Ricardo Márquez-Velasco, Felipe Massó, Malinalli Brianza-Padilla, Daniel Manzur-Sandoval, Julieta González-Flores, Carlos García-Ávila, Yaneli Juárez-Vicuña, Fausto Sánchez-Muñoz, Martha A Ballinas-Verdugo, Edna Basilio-Gálvez, Araceli Paez-Arenas, Mauricio Castillo-Salazar, Sergio Cásares-Alvarado, Adrián Hernández-Diazcouder, José L Sánchez-Gloria, Claudia Tavera-Alonso, Rodrigo Gopar-Nieto, Julio Sandoval |
| المصدر: | Therapeutic Advances in Respiratory Disease, Vol 16 (2022) |
| بيانات النشر: | SAGE Publishing, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | Diseases of the respiratory system, RC705-779 |
| الوصف: | Background: Information about angiotensin II (Ang II), angiotensin-converting enzyme 2 (ACE2), and Ang-(1–7) levels in patients with COVID-19 is scarce. Objective: To characterize the Ang II–ACE2–Ang-(1–7) axis in patients with SARS-CoV-2 infection to understand its role in pathogenesis and prognosis. Methods: Patients greater than 18 years diagnosed with COVID-19, based on clinical findings and positive RT-PCR test, who required hospitalization and treatment were included. We compared Ang II, aldosterone, Ang-(1–7), and Ang-(1–9) concentrations and ACE2 concentration and activity between COVID-19 patients and historic controls. We compared baseline demographics, laboratory results (enzyme, peptide, and inflammatory marker levels), and outcome (patients who survived versus those who died). Results: Serum from 74 patients [age: 58 (48–67.2) years; 68% men] with moderate (20%) or severe (80%) COVID-19 were analyzed. During 13 (10–21) days of hospitalization, 25 patients died from COVID-19 and 49 patients survived. Compared with controls, Ang II concentration was higher and Ang-(1–7) concentration was lower, despite significantly higher ACE2 activity in patients. Ang II concentration was higher and Ang-(1–7) concentration was lower in patients who died. The Ang II/Ang-(1–7) ratio was significantly higher in patients who died. In multivariate analysis, Ang II/Ang-(1–7) ratio greater than 3.45 (OR = 5.87) and lymphocyte count ⩽0.65 × 10 3 /µl (OR = 8.43) were independent predictors of mortality from COVID-19. Conclusion: In patients with severe SARS-CoV-2 infection, imbalance in the Ang II–ACE2–Ang-(1–7) axis may reflect deleterious effects of Ang II and may indicate a worse outcome. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1753-4666 17534666 |
| Relation: | https://doaj.org/toc/1753-4666 |
| DOI: | 10.1177/17534666221122544 |
| URL الوصول: | https://doaj.org/article/78c43c6947294aaaae6435b9fae4f8ef |
| رقم الانضمام: | edsdoj.78c43c6947294aaaae6435b9fae4f8ef |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17534666 |
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| DOI: | 10.1177/17534666221122544 |