Academic Journal
Exploring the significance of glycosylation in prostate cancer subtyping through single-cell analysis
| العنوان: | Exploring the significance of glycosylation in prostate cancer subtyping through single-cell analysis |
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| المؤلفون: | Shijun Tong, Wenhui Zhu, Jing Zhai, Guanxiong Ding |
| المصدر: | Journal of Men's Health, Vol 20, Iss 3, Pp 32-44 (2024) |
| بيانات النشر: | MRE Press, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | prostate cancer, glycosylation, single-cell analysis, subtyping, Medicine (General), R5-920 |
| الوصف: | Prostate cancer impacts millions of men worldwide and causes significant disease burden. Glycosylation is the post-translational modification offering novel therapeutics for prostate cancer. The scRNA-seq data is combined with bulk RNA-seq data of prostate cancer to understand the glycosylation role and identify the therapeutic targets. This study aims to investigate the differences within tumor and the role of glycosylation. The findings confirm that glycosylation can establish multiple cell biomarkers and divide the cell subtypes of prostate cancer. The specific cell subtypes have diverse functions in cell interactions, transcript activity, prognosis and immunotherapy response, such as UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7+ (GALNT7+) epithelial cells and UDP Glucose Ceramide Glucosyltransferase+ (UGCG+) cancer associated macrophages. These outcomes assist in the better understanding of prostate cancer and provide new approach of the targeted therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1875-6867 1875-6859 |
| Relation: | https://oss.jomh.org/files/article/20240329-233/pdf/JOMH2023060501.pdf; https://doaj.org/toc/1875-6867; https://doaj.org/toc/1875-6859 |
| DOI: | 10.22514/jomh.2024.036 |
| URL الوصول: | https://doaj.org/article/c78a43c003a54dce9437ad7fc817afe5 |
| رقم الانضمام: | edsdoj.78a43c003a54dce9437ad7fc817afe5 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 18756867 18756859 |
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| DOI: | 10.22514/jomh.2024.036 |