Academic Journal
Assessing the outcomes of prescribing angiotensin converting enzyme inhibitors and angiotensin receptor blockers for COVID-19 patients
العنوان: | Assessing the outcomes of prescribing angiotensin converting enzyme inhibitors and angiotensin receptor blockers for COVID-19 patients |
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المؤلفون: | Wissam Mekary, Souha Fares, Farah Abdulhai, Gaelle Massoud, Marwan Refaat, Mathias Mericskay, George W. Booz, Fouad A. Zouein |
المصدر: | Heliyon, Vol 9, Iss 9, Pp e19373- (2023) |
بيانات النشر: | Elsevier, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
مصطلحات موضوعية: | SARS-CoV-2, Renin angiotensin aldosterone system, Cardiac biomarkers, Inflammatory biomarkers, Inflammation, Cytokines, Science (General), Q1-390, Social sciences (General), H1-99 |
الوصف: | Background: Patients with heart failure were affected severely by COVID-19. Most heart failure patients are on guideline directed medical therapy, which includes ACE inhibitors (ACEI) and ARBs. These medications were controversial at the beginning of the pandemic due to their interplay with the receptor that SARS-CoV-2 binds in the lungs. We investigated the effect that ACEI and ARB had on patients with hypertension, coronary artery disease, and heart failure. Methods: We recruited 176 patients with COVID-19 infection and cardiovascular comorbidities at the American University of Beirut Medical Center in Lebanon. Of these, 110 patients were taking ACEI or ARB and 66 were not. We collected clinical data and looked at inflammatory markers such as CRP and IL-6 and cardiac markers such as troponin T. We also reported the incidence of ARDS, sepsis, and death of each patient, and compared the 2 groups. Results: We found that patients taking ACEI and ARB had a statistically significant decrease in levels of troponin T, IL-6, and CRP compared to patients not taking these medications (p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2405-8440 |
Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023065817; https://doaj.org/toc/2405-8440 |
DOI: | 10.1016/j.heliyon.2023.e19373 |
URL الوصول: | https://doaj.org/article/789d028b1d4049598def7dc60fc1b0f3 |
رقم الانضمام: | edsdoj.789d028b1d4049598def7dc60fc1b0f3 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 24058440 |
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DOI: | 10.1016/j.heliyon.2023.e19373 |