Academic Journal
Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients
| العنوان: | Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients |
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| المؤلفون: | Alessandro D. Genazzani, Christian Battipaglia, Laura Rusce, Greta Prampolini, Claudia Aio, Francesco Ricciardiello, Martina Foschi, Alessandra Sponzilli, Elisa Semprini, Tabatha Petrillo |
| المصدر: | Gynecological Endocrinology, Vol 40, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Gynecology and obstetrics LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | PCOS, insulin resistance, C-peptide, alpha lipoic acid, familial diabetes, NAFLD, Gynecology and obstetrics, RG1-991, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Objective To evaluate the effects of alpha lipoic acid (ALA) on hormonal and metabolic parameters in a group of overweight/obese Polycystic Ovary Syndrome (PCOS) patients.Methods This was a retrospective study in which thirty-two overweight/obese patients with PCOS (n = 32) not requiring hormonal treatment were selected from the database of the ambulatory clinic of the Gynecological Endocrinology Center at the University of Modena and Reggio Emilia, Italy. The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of complementary treatment with ALA (400 mg/day). Hepatic Insulin Extraction (HIE) index was also calculated.Results ALA administration significantly improved insulin sensitivity and decreased ALT and AST plasma levels in all subjects, though no changes were observed on reproductive hormones. When PCOS patients were subdivided according to the presence or absence of familial diabetes background, the higher effects of ALA were observed in the former group that showed AST and ALT reduction and greater HIE index decrease.Conclusion ALA administration improved insulin sensitivity in overweight/obese PCOS patients, especially in those with familial predisposition to diabetes. ALA administration improved both peripheral sensitivity to insulin and liver clearance of insulin. Such effects potentially decrease the risk of nonalcoholic fat liver disease and diabetes in PCOS patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 09513590 1473-0766 0951-3590 |
| Relation: | https://doaj.org/toc/0951-3590; https://doaj.org/toc/1473-0766 |
| DOI: | 10.1080/09513590.2024.2341701 |
| URL الوصول: | https://doaj.org/article/c7820e8279a24bee8bf9850b8cc13495 |
| رقم الانضمام: | edsdoj.7820e8279a24bee8bf9850b8cc13495 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 09513590 14730766 |
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| DOI: | 10.1080/09513590.2024.2341701 |