التفاصيل البيبلوغرافية
| العنوان: |
Host Innate Antiviral Response to Influenza A Virus Infection: From Viral Sensing to Antagonism and Escape |
| المؤلفون: |
Wenlong An, Simran Lakhina, Jessica Leong, Kartik Rawat, Matloob Husain |
| المصدر: |
Pathogens, Vol 13, Iss 7, p 561 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
influenza virus, Toll-like receptors, RIG-I, NOD-like receptors, NLRP3 inflammasome, ZBP1, Medicine |
| الوصف: |
Influenza virus possesses an RNA genome of single-stranded, negative-sensed, and segmented configuration. Influenza virus causes an acute respiratory disease, commonly known as the “flu” in humans. In some individuals, flu can lead to pneumonia and acute respiratory distress syndrome. Influenza A virus (IAV) is the most significant because it causes recurring seasonal epidemics, occasional pandemics, and zoonotic outbreaks in human populations, globally. The host innate immune response to IAV infection plays a critical role in sensing, preventing, and clearing the infection as well as in flu disease pathology. Host cells sense IAV infection through multiple receptors and mechanisms, which culminate in the induction of a concerted innate antiviral response and the creation of an antiviral state, which inhibits and clears the infection from host cells. However, IAV antagonizes and escapes many steps of the innate antiviral response by different mechanisms. Herein, we review those host and viral mechanisms. This review covers most aspects of the host innate immune response, i.e., (1) the sensing of incoming virus particles, (2) the activation of downstream innate antiviral signaling pathways, (3) the expression of interferon-stimulated genes, (4) and viral antagonism and escape. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-0817 |
| Relation: |
https://www.mdpi.com/2076-0817/13/7/561; https://doaj.org/toc/2076-0817 |
| DOI: |
10.3390/pathogens13070561 |
| URL الوصول: |
https://doaj.org/article/77ff552fed964a83ae89c691df71f7fe |
| رقم الانضمام: |
edsdoj.77ff552fed964a83ae89c691df71f7fe |
| قاعدة البيانات: |
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