Academic Journal
A portable high-intensity focused ultrasound system for the pancreas with 3D electronic steering: a preclinical study in a swine model
| العنوان: | A portable high-intensity focused ultrasound system for the pancreas with 3D electronic steering: a preclinical study in a swine model |
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| المؤلفون: | Won Chang, Jae Young Lee, Jae Hwan Lee, Jae Seok Bae, Yeon Jin Cho, Kook Jin Kang, Keonho Son, Yul Ri Chung, Kyoung Bun Lee, Joon Koo Han |
| المصدر: | Ultrasonography, Vol 37, Iss 4, Pp 298-306 (2018) |
| بيانات النشر: | Korean Society of Ultrasound in Medicine, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medical technology |
| مصطلحات موضوعية: | High-intensity focused ultrasound, Animal research, Pancreas, Medical technology, R855-855.5 |
| الوصف: | Purpose The aim of this animal study was to evaluate the safety and feasibility of a portable, ultrasonography-guided, high-intensity focused ultrasound (USg-HIFU) system to treat the pancreas. Methods Eight swine were included. Using a portable HIFU device (ALPIUS 900, Alpinion Medical Systems), ablations were performed on the pancreas in vivo. Different acoustic intensities were applied (1.7 kW/cm2 or 1.5 kW/cm2, n=2 [group A for a pilot study]; 1.5 kW/ cm2, n=3 [group B]; and 1.2 kW/cm2, n=3 [group C]). Magnetic resonance imaging (MRI) was performed immediately (group A) or 7 days (groups B and C) after HIFU treatment. In groups B and C, serum amylase and lipase levels were measured on days 0 and 7, and performance status was observed every day. Necropsy was performed on days 0 (group A) or 7 (groups B and C) to assess the presence of unintended injuries and to obtain pancreatic and peripancreatic tissue for histological analysis. Results Ablation was noted in the pancreas in all swine on MRI, and all pathologic specimens showed coagulation necrosis in the treated area. The mean ablation areas on MRI were 85.3±38.1 mm2, 90.7±21.2 mm2, and 54.4±30.6 mm2 in groups A, B, and C, respectively (P>0.05). No animals showed evidence of complications, except for one case of a pseudocyst in group B. Conclusion This study showed that pancreas ablation using a portable USg-HIFU system may be safe and feasible, and that coagulation necrosis of the pancreas was successfully achieved with a range of acoustic intensities. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2288-5919 2288-5943 |
| Relation: | http://www.e-ultrasonography.org/upload/usg-17048.pdf; https://doaj.org/toc/2288-5919; https://doaj.org/toc/2288-5943 |
| DOI: | 10.14366/usg.17048 |
| URL الوصول: | https://doaj.org/article/ea77f87ce9a74004b26bd1a9c6d55cb5 |
| رقم الانضمام: | edsdoj.77f87ce9a74004b26bd1a9c6d55cb5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22885919 22885943 |
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| DOI: | 10.14366/usg.17048 |