Academic Journal
External validation of the five domains of negative symptoms: Focus on cognition, functional capacity, and real-world functioning
| العنوان: | External validation of the five domains of negative symptoms: Focus on cognition, functional capacity, and real-world functioning |
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| المؤلفون: | Giulia M. Giordano, Francesco Sanmarchi, Armida Mucci, Paola Rucci, Francesco Brando, Edoardo Caporusso, Luigi Giuliani, Antonio Melillo, Pasquale Pezzella, Paola Bucci, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Rodolfo Rossi, Giulio Pergola, Silvana Galderisi, Mario Maj |
| المصدر: | European Psychiatry, Vol 67 (2024) |
| بيانات النشر: | Cambridge University Press, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Psychiatry |
| مصطلحات موضوعية: | BNSS, cognition, five-factor model, functional capacity, hierarchical model, negative symptoms, Psychiatry, RC435-571 |
| الوصف: | Abstract Background The conceptualization of negative symptoms (NS) in schizophrenia is still controversial. Recent confirmatory factor-analytic studies suggested that the bi-dimensional model (motivational deficit [MAP] and expressive deficit [EXP]) may not capture the complexity of NS structure, which could be better defined by a five-factor (five NS domains) or a hierarchical model (five NS domains as first-order factors, and MAP and EXP, as second-order factors). A validation of these models is needed to define the structure of NS. To evaluate the validity and temporal stability of the five-factor or the hierarchical structure of the brief negative symptom scale (BNSS) in individuals with schizophrenia (SCZ), exploring associations between these models with cognition, social cognition, functional capacity, and functioning at baseline and at 4 years follow-up. Methods Clinical variables were assessed using state-of-the-art tools in 612 SCZ at two-time points. The validity of the five-factor and the hierarchical models was analyzed through structural equation models. Results The two models had both a good fit and showed a similar pattern of associations with external validators at the two-time points, with minor variations. The five-factor solution had a slightly better fit. The associations with external validators favored the five-factor structure. Conclusions Our findings suggest that both five-factor and hierarchical models provide a valid conceptualization of NS in relation to external variables and that five-factor solution provides the best balance between parsimony and granularity to summarize the BNSS structure. This finding has important implications for the study of pathophysiological mechanisms and the development of new treatments. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0924-9338 1778-3585 |
| Relation: | https://www.cambridge.org/core/product/identifier/S0924933823024781/type/journal_article; https://doaj.org/toc/0924-9338; https://doaj.org/toc/1778-3585 |
| DOI: | 10.1192/j.eurpsy.2023.2478 |
| URL الوصول: | https://doaj.org/article/77d2e04e23974e7cbe2c36a524991c1d |
| رقم الانضمام: | edsdoj.77d2e04e23974e7cbe2c36a524991c1d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09249338 17783585 |
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| DOI: | 10.1192/j.eurpsy.2023.2478 |