التفاصيل البيبلوغرافية
| العنوان: |
Comparison of antiviral responses in two bat species reveals conserved and divergent innate immune pathways |
| المؤلفون: |
Lilach Schneor, Stefan Kaltenbach, Sivan Friedman, Dafna Tussia-Cohen, Yomiran Nissan, Gal Shuler, Evgeny Fraimovitch, Aleksandra A. Kolodziejczyk, Maya Weinberg, Giacomo Donati, Emma C. Teeling, Yossi Yovel, Tzachi Hagai |
| المصدر: |
iScience, Vol 26, Iss 8, Pp 107435- (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
biological sciences, Immunology, evolutionary biology, Phylogenetics, transcriptomics, Science |
| الوصف: |
Summary: Bats host a range of disease-causing viruses without displaying clinical symptoms. The mechanisms behind this are a continuous source of interest. Here, we studied the antiviral response in the Egyptian fruit bat and Kuhl’s pipistrelle, representing two subordinal clades. We profiled the antiviral response in fibroblasts using RNA sequencing and compared bat with primate and rodent responses. Both bats upregulate similar genes; however, a subset of these genes is transcriptionally divergent between them. These divergent genes also evolve rapidly in sequence, have specific promoter architectures, and are associated with programs underlying tolerance and resistance. Finally, we characterized antiviral genes that expanded in bats, with duplicates diverging in sequence and expression.Our study reveals a largely conserved antiviral program across bats and points to a set of genes that rapidly evolve through multiple mechanisms. These can contribute to bat adaptation to viral infection and provide directions to understanding the mechanisms behind it. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004223015122; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2023.107435 |
| URL الوصول: |
https://doaj.org/article/77c73c641cc74f0d9177a6ee9c387449 |
| رقم الانضمام: |
edsdoj.77c73c641cc74f0d9177a6ee9c387449 |
| قاعدة البيانات: |
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