التفاصيل البيبلوغرافية
| العنوان: |
Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways |
| المؤلفون: |
Lin Deng, Muchamad Ridotu Solichin, Dewa Nyoman Murti Adyaksa, Maria Alethea Septianastiti, Rhamadianti Aulia Fitri, Gede Ngurah Rsi Suwardan, Chieko Matsui, Takayuki Abe, Ikuo Shoji |
| المصدر: |
Viruses, Vol 15, Iss 12, p 2430 (2023) |
| بيانات النشر: |
MDPI AG, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
hepatitis C virus, release, Golgi, recycling endosome, multivesicular bodies, endosomal sorting complex required for transport machinery, Microbiology, QR1-502 |
| الوصف: |
Hepatitis C virus (HCV) is a positive-sense, single-stranded RNA virus that causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The release of infectious HCV particles from infected hepatocytes is a crucial step in viral dissemination and disease progression. While the exact mechanisms of HCV particle release remain poorly understood, emerging evidence suggests that HCV utilizes intracellular membrane trafficking and secretory pathways. These pathways include the Golgi secretory pathway and the endosomal trafficking pathways, such as the recycling endosome pathway and the endosomal sorting complex required for transport (ESCRT)-dependent multivesicular bodies (MVBs) pathway. This review provides an overview of recent advances in understanding the release of infectious HCV particles, with a particular focus on the involvement of the host cell factors that participate in HCV particle release. By summarizing the current knowledge in this area, this review aims to contribute to a better understanding of endosomal pathways involved in the extracellular release of HCV particles and the development of novel antiviral strategies. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/15/12/2430; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v15122430 |
| URL الوصول: |
https://doaj.org/article/779b24b2ec9940b1888e157619e4f321 |
| رقم الانضمام: |
edsdoj.779b24b2ec9940b1888e157619e4f321 |
| قاعدة البيانات: |
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