التفاصيل البيبلوغرافية
| العنوان: |
Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms |
| المؤلفون: |
Therese Torgersen Bigseth, John Abel Engh, Jens Egeland, Eivind Andersen, Ole Andreas Andreassen, Gry Bang-Kittilsen, Ragnhild Sørum Falk, Tom Langerud Holmen, Morten Lindberg, Jon Mordal, Jimmi Nielsen, Nils Eiel Steen, Thor Ueland, Torkel Vang, Mats Fredriksen |
| المصدر: |
BMC Psychiatry, Vol 21, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: |
BMC, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Psychiatry |
| مصطلحات موضوعية: |
Schizophrenia, Depression, suPAR, Urokinase, CRP, Inflammation, Psychiatry, RC435-571 |
| الوصف: |
Abstract Background There is evidence of increased low grade inflammation (LGI) in schizophrenia patients. However, the inter-individual variation is large and the association with demographic, somatic and psychiatric factors remains unclear. Our aim was to explore whether levels of the novel LGI marker soluble urokinase plasminogen activator receptor (suPAR) were associated with clinical factors in schizophrenia and if such associations were sex-dependent. Method In this observational study a total of 187 participants with schizophrenia (108 males, 79 females) underwent physical examination and assessment with clinical interviews (Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Alcohol Use Disorder Identification Test (AUDIT), and Drug Use Disorder Identification Test (DUDIT)). Blood levels of suPAR, glucose, lipids, and high sensitivity C-reactive protein (hsCRP) were determined and body mass index (BMI) calculated. Multivariable linear regression analyses were used adjusting for confounders, and sex interaction tested in significant variables. Results Adjusting for sex, age, current tobacco smoking and BMI, we found that levels of hsCRP and depressive symptoms (CDSS) were positively associated with levels of suPAR (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-244X |
| Relation: |
https://doaj.org/toc/1471-244X |
| DOI: |
10.1186/s12888-021-03522-6 |
| URL الوصول: |
https://doaj.org/article/775491c5ffc741559d724b8a5ca68d3a |
| رقم الانضمام: |
edsdoj.775491c5ffc741559d724b8a5ca68d3a |
| قاعدة البيانات: |
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