التفاصيل البيبلوغرافية
| العنوان: |
Altered Brain Activity in Patients With Comitant Strabismus Detected by Analysis of the Fractional Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study |
| المؤلفون: |
Meng-Yan Hu, Yi-Cong Pan, Li-Juan Zhang, Rong-Bin Liang, Qian-Min Ge, Hui-Ye Shu, Qiu-Yu Li, Chong-Gang Pei, Yi Shao |
| المصدر: |
Frontiers in Human Neuroscience, Vol 16 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
fractional amplitude of low-frequency fluctuation, comitant strabismus, brain changes, depression and anxiety, resting-state functional magnetic resonance imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
More and more studies showed that strabismus is not simply an ocular disease, but a neuro-ophthalmology disease. To analyze potential changes in brain activity and their relationship to behavioral performance in comitant strabismus patients and healthy controls. Our study recruited 28 patients with comitant strabismus and 28 people with matched weight, age range, and sex ratio as healthy controls. Using resting-state functional magnetic resonance imaging, we evaluated fALFF to compare spontaneous brain activity between comitant strabismus and healthy controls. We did hospital anxiety and depression scale questionnaires for these patients. We found significantly lower fALFF value in comitant strabismus patients compared with controls in the left frontal superior medial gyrus and the right middle cingulum. In the latter region, fALFF was significantly negatively correlated with the hospital anxiety and depression scale, as well as the duration of disease. Receiver operating characteristic curve analysis indicated that the fALFF method has clear potential for the diagnosis of comitant strabismus patients. These results revealed abnormal spontaneous activity in two brain regions of comitant strabismus patients, which may indicate underlying pathologic mechanisms and may help to advance clinical treatment. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1662-5161 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnhum.2022.874703/full; https://doaj.org/toc/1662-5161 |
| DOI: |
10.3389/fnhum.2022.874703 |
| URL الوصول: |
https://doaj.org/article/75c75b66064145c39fe9d3b41861c69f |
| رقم الانضمام: |
edsdoj.75c75b66064145c39fe9d3b41861c69f |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder