Academic Journal
An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus
| العنوان: | An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus |
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| المؤلفون: | Thi-Minh Nguyen, Dietmar Schreiner, Le Xiao, Lisa Traunmüller, Caroline Bornmann, Peter Scheiffele |
| المصدر: | eLife, Vol 5 (2016) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | synaptic specificity, alternative splicing, GABA, synaptogenesis, activity, memory, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The unique anatomical and functional features of principal and interneuron populations are critical for the appropriate function of neuronal circuits. Cell type-specific properties are encoded by selective gene expression programs that shape molecular repertoires and synaptic protein complexes. However, the nature of such programs, particularly for post-transcriptional regulation at the level of alternative splicing is only beginning to emerge. We here demonstrate that transcripts encoding the synaptic adhesion molecules neurexin-1,2,3 are commonly expressed in principal cells and interneurons of the mouse hippocampus but undergo highly differential, cell type-specific alternative splicing. Principal cell-specific neurexin splice isoforms depend on the RNA-binding protein Slm2. By contrast, most parvalbumin-positive (PV+) interneurons lack Slm2, express a different neurexin splice isoform and co-express the corresponding splice isoform-specific neurexin ligand Cbln4. Conditional ablation of Nrxn alternative splice insertions selectively in PV+ cells results in elevated hippocampal network activity and impairment in a learning task. Thus, PV-cell-specific alternative splicing of neurexins is critical for neuronal circuit function |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/22757; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.22757 |
| URL الوصول: | https://doaj.org/article/758f12f56cc44872a3e461fcdd592489 |
| رقم الانضمام: | edsdoj.758f12f56cc44872a3e461fcdd592489 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.22757 |