Academic Journal
Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy
| العنوان: | Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy |
|---|---|
| المؤلفون: | Yuki Matsui, MD, PhD, Hirotaka Kishi, MD, Chihiro Matsui, MD, Jun Morita, MD, PhD, Hiroshi Mizuno, MD, PhD, Hatan Mortada, MBBS, Haruaki Sasaki, MD, PhD, Takashi Fukagai, MD, PhD |
| المصدر: | Plastic and Reconstructive Surgery, Global Open, Vol 13, Iss 1, p e6423 (2025) |
| بيانات النشر: | Wolters Kluwer, 2025. |
| سنة النشر: | 2025 |
| المجموعة: | LCC:Surgery |
| مصطلحات موضوعية: | Surgery, RD1-811 |
| الوصف: | Background:. Chemotherapy-induced peripheral neuropathy (CIPN) affects 29%–68% of patients undergoing anticancer treatments within the first month. Traditional cryotherapy methods, such as frozen gloves, can pose risks. This study evaluates the cool-water electric circulation seat (CECS), which maintains a constant 15°C, as a safer alternative. Methods:. In this prospective study, 21 healthy Japanese adults underwent 2.5 hours of hand cooling at 15°C, reflecting the standard duration of taxane anticancer drug administration. Microcirculation was evaluated using videocapillaroscopy before and after cooling. Results:. Results showed significant reductions in blood vessel area and altered red blood cell movement postcooling. Finger temperature and vascular area decreased significantly (P < 0.001), and red blood cell movement changed significantly, with most cells shifting from slow (52.4%) or fast (47.6%) movement before cooling to slow (23.8%) or immobile (76.2%) afterward (P < 0.001). Thirty minutes postcooling, 38.1% of participants reported temporary redness, and 28.6% reported pain, both resolving by the next day. Conclusions:. The CECS effectively provides secure cooling, offering a promising approach for CIPN prevention without frostbite risk. These findings highlight the potential advantages of CECS in sustained cooling therapy for CIPN prevention. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2169-7574 00000000 |
| Relation: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006423; https://doaj.org/toc/2169-7574 |
| DOI: | 10.1097/GOX.0000000000006423 |
| URL الوصول: | https://doaj.org/article/d7505f04ba6741f0b0336433ef0d8151 |
| رقم الانضمام: | edsdoj.7505f04ba6741f0b0336433ef0d8151 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21697574 00000000 |
|---|---|
| DOI: | 10.1097/GOX.0000000000006423 |