Academic Journal
Prognostic Value of Plasma Endothelin-1 in Predicting Worse Outcomes in Patients with Prediabetes and Diabetes and Stable Coronary Artery Diseases
| العنوان: | Prognostic Value of Plasma Endothelin-1 in Predicting Worse Outcomes in Patients with Prediabetes and Diabetes and Stable Coronary Artery Diseases |
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| المؤلفون: | Cheng Yang, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Qian Dong, Rui-Xia Xu, Yong-Jian Wu, Jie Qian, Jian-Jun Li |
| المصدر: | Diabetes & Metabolism Journal, Vol 48, Iss 5, Pp 993-1002 (2024) |
| بيانات النشر: | Korean Diabetes Association, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | coronary artery disease, diabetes mellitus, endothelin-1, prediabetic state, prognosis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Background Endothelin-1 (ET-1) is an endogenous vasoconstrictor implicated in coronary artery disease (CAD) and diabetes. This study aimed to determine the prognostic value of ET-1 in the patients with stable CAD under different glucose metabolism states. Methods In this prospective, large-cohort study, we consecutively enrolled 7,947 participants with angiography-diagnosed stable CAD from April 2011 to April 2017. Patients were categorized by baseline glycemic status into three groups (normoglycemia, prediabetes, and diabetes) and further divided into nine groups by circulating ET-1 levels. Patients were followed for the occurrence of cardiovascular events (CVEs), including nonfatal myocardial infarction, stroke, and cardiovascular mortality. Results Of the 7,947 subjects, 3,352, 1,653, and 2,942 had normoglycemia, prediabetes, and diabetes, respectively. Over a median follow-up of 37.5 months, 381 (5.1%) CVEs occurred. The risk for CVEs was significantly higher in patients with elevated ET-1 levels after adjustment for potential confounders. When patients were categorized by both status of glucose metabolism and plasma ET-1 levels, the high ET-1 levels were associated with higher risk of CVEs in prediabetes (adjusted hazard ratio [HR], 2.089; 95% confidence interval [CI], 1.151 to 3.793) and diabetes (adjusted HR, 2.729; 95% CI, 1.623 to 4.588; both P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2233-6079 2233-6087 |
| Relation: | http://www.e-dmj.org/upload/pdf/dmj-2023-0410.pdf; https://doaj.org/toc/2233-6079; https://doaj.org/toc/2233-6087 |
| DOI: | 10.4093/dmj.2023.0410 |
| URL الوصول: | https://doaj.org/article/e74bf2c6e60a4ccfacb7150b3ce0f362 |
| رقم الانضمام: | edsdoj.74bf2c6e60a4ccfacb7150b3ce0f362 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22336079 22336087 |
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| DOI: | 10.4093/dmj.2023.0410 |