Academic Journal
Dynamic thiol/disulphide homeostasis in acute urticaria
| العنوان: | Dynamic thiol/disulphide homeostasis in acute urticaria |
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| المؤلفون: | Yavuz Otal, Neslihan Özkök Koz, Fatih Ahmet Kahraman, F Güllü Haydar Ercan, Özcan Erel, Gamze Avcıoğlu |
| المصدر: | Indian Journal of Dermatology, Vol 66, Iss 5, Pp 449-453 (2021) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Dermatology |
| مصطلحات موضوعية: | acute urticaria, ischemia-modified albumin, neutrophil lymphocyte ratio, oxidative stress, thiol-disulphide homeostasis, Dermatology, RL1-803 |
| الوصف: | Background: Urticaria is an unknown, sudden, and itchy skin disease that is recognized with redness, swelling, and is sometimes seen with angioedema. It is classified as acute or chronic, depending on the duration of symptoms. Thiols in plasma are powerful antioxidants that physiologically eliminate free radicals. The mostly and rapidly affected proteins are thiols that contain the sulfhydryl group. In the present study, the thiol/disulfide homeostasis was investigated as a brand new indicator of oxidative stress in patients who had acute urticaria and presented to the emergency department. Objective: In the present study, the thiol/disulfide homeostasis, ischemia-modified albumin (IMA), and and neutrophil lymphocyte ratio (N/L ratio) were investigated in the etiopathogenesis of acute urticaria. Material and Method: A total of 37 patients and 40 healthy volunteers were included in the study. Thiol/disulfide homeostasis (TDH) [total thiol-native thiol/disulfide changes] was measured in both groups (patient group and control group) using a brand novel method developed by Erel and Neselioglu. Half of the difference between total thiol and native thiol concentrations gives the amount of disulfide bond. Results: Total thiol and native thiol levels in blood were found to be low. The levels of total thiol (P = 0.218) and native thiol (P = 0,001) were significantly lower in patients with acute urticaria than in the control group. At the same time, the level of disulfide was significantly higher in the patient group than in the control group (P = |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0019-5154 1998-3611 |
| Relation: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2021;volume=66;issue=5;spage=449;epage=453;aulast=Otal; https://doaj.org/toc/0019-5154; https://doaj.org/toc/1998-3611 |
| DOI: | 10.4103/ijd.IJD_152_19 |
| URL الوصول: | https://doaj.org/article/749c92f9f429490f9e441e08a19a9fec |
| رقم الانضمام: | edsdoj.749c92f9f429490f9e441e08a19a9fec |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00195154 19983611 |
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| DOI: | 10.4103/ijd.IJD_152_19 |