Academic Journal
GABAergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex
| العنوان: | GABAergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex |
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| المؤلفون: | Yuan Gao, Yong-Chun Cai, Dong-Yu Liu, Juan Yu, Jue Wang, Ming Li, Bin Xu, Tengfei Wang, Gang Chen, Georg Northoff, Ruiliang Bai, Xue Mei Song |
| المصدر: | eLife, Vol 13 (2024) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | human MT complex, γ-aminobutyric acid, fluid intelligence, magnetic resonance spectroscopy, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The prevailing opinion emphasizes fronto-parietal network (FPN) is key in mediating general fluid intelligence (gF). Meanwhile, recent studies show that human MT complex (hMT+), located at the occipito-temporal border and involved in 3D perception processing, also plays a key role in gF. However, the underlying mechanism is not clear, yet. To investigate this issue, our study targets visuo-spatial intelligence, which is considered to have high loading on gF. We use ultra-high field magnetic resonance spectroscopy (MRS) to measure GABA/Glu concentrations in hMT+ combining resting-state fMRI functional connectivity (FC), behavioral examinations including hMT+ perception suppression test and gF subtest in visuo-spatial component. Our findings show that both GABA in hMT+ and frontal-hMT+ functional connectivity significantly correlate with the performance of visuo-spatial intelligence. Further, serial mediation model demonstrates that the effect of hMT+ GABA on visuo-spatial gF is fully mediated by the hMT+ frontal FC. Together our findings highlight the importance in integrating sensory and frontal cortices in mediating the visuo-spatial component of general fluid intelligence. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/97545; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.97545 |
| URL الوصول: | https://doaj.org/article/747705e380c2480189a1712e7b9eb2b6 |
| رقم الانضمام: | edsdoj.747705e380c2480189a1712e7b9eb2b6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.97545 |