Academic Journal
Sirtuin 1, as a potential prognosis marker in renal clear cell carcinoma, regulates lipid metabolism and immune infiltration
| العنوان: | Sirtuin 1, as a potential prognosis marker in renal clear cell carcinoma, regulates lipid metabolism and immune infiltration |
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| المؤلفون: | Xuefei Wang, Fangqi Deng, Jiexi Liu, Jiayu Wang, Qing Chen, Jiabin Lu |
| المصدر: | Biomolecules & Biomedicine (2024) |
| بيانات النشر: | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Renal clear cell carcinoma (ccRCC), Sirtuin 1 (Sirt1), prognosis, lipid metabolism disorder, immune infiltration, Biology (General), QH301-705.5 |
| الوصف: | Renal clear cell carcinoma (ccRCC) is a malignancy with a dismal prognosis, caused by the buildup of fat and glycogen. Sirtuin 1 (Sirt1) is a deacetylase that regulates lipid metabolism. In this study, we collected tumor and paracancer tissues from 386 ccRCC patients and followed their prognosis over an extended time period. The expression of Sirt1 in these tissues was assessed using immunohistochemistry, and LinkedOmics database analysis identified differentially expressed genes associated with Sirt1. The survival curve was generated using the Kaplan-Meier method, and immune infiltration was analyzed using the Tumor Immune Estimation Resource (TIMER) web tool. Our findings revealed that Sirt1 was expressed in tumor tissues, but not in normal tissues, and its high expression was associated with a worse prognosis. Furthermore, we observed a positive correlation between high Sirt1 expression and perirenal fat invasion and necrosis, leading to poorer survival outcomes. We established a nomogram to predict prognosis, and a correlation was observed with immune infiltration. In conclusion, our results suggest that high Sirt1 expression is associated with lipid metabolism disorder and immune infiltration, ultimately contributing to a dismal prognosis in ccRCC. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2831-0896 2831-090X |
| Relation: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/10304; https://doaj.org/toc/2831-0896; https://doaj.org/toc/2831-090X |
| DOI: | 10.17305/bb.2024.10304 |
| URL الوصول: | https://doaj.org/article/73d7fc955ea04c688dfad691213f3dd4 |
| رقم الانضمام: | edsdoj.73d7fc955ea04c688dfad691213f3dd4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 28310896 2831090X |
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| DOI: | 10.17305/bb.2024.10304 |