Academic Journal

Vitamin D treatment distinctly modulates cytokine production by peripheral blood mononuclear cells among patients with chronic cardiac and indeterminate clinical forms of Chagas disease

التفاصيل البيبلوغرافية
العنوان: Vitamin D treatment distinctly modulates cytokine production by peripheral blood mononuclear cells among patients with chronic cardiac and indeterminate clinical forms of Chagas disease
المؤلفون: Kamila Kássia dos Santos Oliveira, Diego José Lira Torres, Michelle da Silva Barros, Leyllane Rafael Moreira, Claudeir Dias da Silva Junior, Ana Karine de Araújo Soares, Maria da Piedade Costa Reis deAlbuquerque, Maria da Glória Aureliano Melo Cavalcante, Wilson Alves de Oliveira Junior, Michelle Christiane da Silva Rabello, Virginia Maria Barros deLorena
المصدر: Immunity, Inflammation and Disease, Vol 12, Iss 9, Pp n/a-n/a (2024)
بيانات النشر: Wiley, 2024.
سنة النشر: 2024
المجموعة: LCC:Immunologic diseases. Allergy
مصطلحات موضوعية: Chagas disease, immune response, vitamin D, Immunologic diseases. Allergy, RC581-607
الوصف: Abstract Introduction Chagas disease is caused by the protozoan Trypanosoma cruzi and is clinically divided into acute and chronic phases. Chronic Chagas cardiomyopathy is the most studied manifestation of the disease. Vitamin D deficiency has been suggested as a risk factor for cardiovascular disease. No studies demonstrate the action of this hormone in the cells of patients with chronic Chagas heart disease. Objective To evaluate the in vitro immunomodulatory effect of vitamin D on peripheral blood mononuclear cells of patients with the different chronic clinical forms of Chagas disease. Evaluating vitamin D's in vitro effect on blood cells by producing cytokines. Methods Thirteen patients of the undetermined form (IND), 13 of the mild cardiac form (CARD1) and 14 of the severe cardiac form (CARD2) of Chagas disease, and 12 with idiopathic heart disease (CARDid) were included. The cells obtained from peripheral blood were treated in vitro with vitamin D (1 × 10−7 M) for 24 h and cytokines were dosed in the culture supernatant. Results Although it was not possible to demonstrate statistically significant differences between the groups studied, our data showed that the cells treated with vitamin D modify (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-4527
Relation: https://doaj.org/toc/2050-4527
DOI: 10.1002/iid3.1330
URL الوصول: https://doaj.org/article/73a2f14665b74f2bbb0c7504cc4625ac
رقم الانضمام: edsdoj.73a2f14665b74f2bbb0c7504cc4625ac
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20504527
DOI:10.1002/iid3.1330