Academic Journal
Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice.
| العنوان: | Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice. |
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| المؤلفون: | Rachel P L van Swelm, Coby M M Laarakkers, Ellen C van der Kuur, Eva Morava-Kozicz, Ron A Wevers, Kevin D Augustijn, Daan J Touw, Maro H Sandel, Rosalinde Masereeuw, Frans G M Russel |
| المصدر: | PLoS ONE, Vol 7, Iss 11, p e49524 (2012) |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) followed by 24 h urine collection. Doses of ≥275 mg/kg bw APAP resulted in hepatic centrilobular necrosis and significantly elevated plasma alanine aminotransferase (ALT) values (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3498140?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0049524 |
| URL الوصول: | https://doaj.org/article/e72eb2e6d83c4354b2efc7eb581a84fb |
| رقم الانضمام: | edsdoj.72eb2e6d83c4354b2efc7eb581a84fb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0049524 |