التفاصيل البيبلوغرافية
| العنوان: |
Identification of natural inhibitors targeting trehalase of Anopheles funestus in the management of malaria: A Biocomputational assessment |
| المؤلفون: |
Amer Al Ali, Abdulaziz Asiri, Mohammed H Abu-Alghayth, Maryam Musleh Althobiti, Bandar Ali Al Hader, Zain Alhindi |
| المصدر: |
Journal of Vector Borne Diseases, Vol 61, Iss 4, Pp 607-613 (2024) |
| بيانات النشر: |
Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: |
anopheles funestus, malaria, trehalase, natural compounds, drug-likeness, Infectious and parasitic diseases, RC109-216 |
| الوصف: |
Background & objectives: Anopheles funestus is playing an increasingly important role in malaria transmission in sub-Saharan Africa. Trehalase, an enzyme required for trehalose breakdown, is important for mosquito flight and stress adaptation. Hence, its inhibition has emerged as a promising malaria management strategy. Methods: A collection of 1900 natural compounds from the ZINC database were screened against the 3D modeled structure of An. funestus trehalase protein using in silico tools. ADMET-AI, a web-based platform, was used to predict the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the selected compounds. Results: We report 5 natural compounds namely, ZINC00488388, ZINC00488525, ZINC00488566, ZINC00488304, and ZINC00488456 that demonstrated strong binding affinity to the trehalase protein. These compounds interacted with critical residues of the trehalase protein and exhibited good drug-like characteristics. Interpretation & conclusion: These compounds show promise as trehalase protein inhibitors for malaria management. Nonetheless, additional experimental studies are required to optimize these compounds as potential trehalase inhibitors. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
0972-9062 |
| Relation: |
https://journals.lww.com/10.4103/JVBD.jvbd_83_24; https://doaj.org/toc/0972-9062 |
| DOI: |
10.4103/JVBD.jvbd_83_24 |
| URL الوصول: |
https://doaj.org/article/72e330a410e440d8a1d4a5d8b335190c |
| رقم الانضمام: |
edsdoj.72e330a410e440d8a1d4a5d8b335190c |
| قاعدة البيانات: |
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