Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project

التفاصيل البيبلوغرافية
العنوان:	Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
المؤلفون:	Dylan E. O’Sullivan, Amy Metcalfe, Troy W. R. Hillier, Will D. King, Sangmin Lee, Joy Pader, Darren R. Brenner
المصدر:	Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Medicine LCC:Science
مصطلحات موضوعية:	Medicine, Science
الوصف:	Abstract The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta’s Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2045-2322
Relation:	https://doaj.org/toc/2045-2322
DOI:	10.1038/s41598-020-76294-w
URL الوصول:	https://doaj.org/article/72cbde3ff3a1489eaee128c0685ade29
رقم الانضمام:	edsdoj.72cbde3ff3a1489eaee128c0685ade29
قاعدة البيانات:	Directory of Open Access Journals

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الوصف
تدمد:	20452322
DOI:	10.1038/s41598-020-76294-w