التفاصيل البيبلوغرافية
| العنوان: |
Generation of two PITX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system |
| المؤلفون: |
Dasom Mun, Ji-Young Kang, Yumin Chun, Da-Seul Park, Hyoeun Kim, Nuri Yun, Seung-Hyun Lee, Boyoung Joung |
| المصدر: |
Stem Cell Research, Vol 65, Iss , Pp 102940- (2022) |
| بيانات النشر: |
Elsevier, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
Biology (General), QH301-705.5 |
| الوصف: |
PITX2 is a homeobox gene located in the human 4q25 locus and is commonly associated with atrial fibrillation (AF). Here, we generated two PITX2 knock-out human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 genome editing. The edited iPSCs maintained full pluripotency, normal karyotype and spontaneous differentiation capability. This cell line provides a suitable model for investigating the physiopathology of PITX2 mutation in atrial fibrillation. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1873-5061 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1873506122002896; https://doaj.org/toc/1873-5061 |
| DOI: |
10.1016/j.scr.2022.102940 |
| URL الوصول: |
https://doaj.org/article/728513e601b34ec4b017545106bd69c1 |
| رقم الانضمام: |
edsdoj.728513e601b34ec4b017545106bd69c1 |
| قاعدة البيانات: |
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