التفاصيل البيبلوغرافية
| العنوان: |
Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas |
| المؤلفون: |
Mennatullah El-Nadi, Hebatallah Hassan, Moshira Ezzat Saleh, Eyyad Nassar, Yahia Mahmoud Ismail, Mahmoud Amer, Burkhard Greve, Martin Götte, Mohamed El-Shinawi, Sherif Abdelaziz Ibrahim |
| المصدر: |
Matrix Biology Plus, Vol 6, Iss , Pp 100030- (2020) |
| بيانات النشر: |
Elsevier, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
Inflammatory breast cancer, Triple negative subtype, Heparanase, Cathepsin L, CD163+ M2-type tumor-associated macrophages, Invasion, Biology (General), QH301-705.5 |
| الوصف: |
Inflammatory breast cancer (IBC) is the most aggressive and lethal form of breast cancer, characterized by a high infiltration of tumor-associated macrophages and poor prognosis. To identify new biomarkers and to elucidate the molecular mechanisms underlying IBC pathogenesis, we investigated the expression pattern of heparanase (HPSE) and its activator cathepsin L (CTSL). First, we quantitated the HPSE and CTSL mRNA levels in a cohort of breast cancer patients after curative surgery (20 IBC and 20-non-IBC). We discovered that both HPSE and CTSL mRNA levels were significantly induced in IBC tissue vis-à-vis non-IBC patients (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2590-0285 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2590028520300119; https://doaj.org/toc/2590-0285 |
| DOI: |
10.1016/j.mbplus.2020.100030 |
| URL الوصول: |
https://doaj.org/article/724fed8bfdb84ff3b692920d8692488d |
| رقم الانضمام: |
edsdoj.724fed8bfdb84ff3b692920d8692488d |
| قاعدة البيانات: |
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