التفاصيل البيبلوغرافية
| العنوان: |
Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease |
| المؤلفون: |
Zhengfang Zhou, Jingying Wang, Chaoshe Guo, Weiting Chang, Jian Zhuang, Ping Zhu, Xue Li |
| المصدر: |
Cell Reports, Vol 18, Iss 4, Pp 1019-1032 (2017) |
| بيانات النشر: |
Elsevier, 2017. |
| سنة النشر: |
2017 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
Six1, Six2, Shh, cardiac outflow tract, persistent truncus arteriosus, PTA, common arterial trunk, tetralogy of Fallot, TOF, intrapericardial arterial trunk, second heart field, cardiac neural crest, progenitor, high-resolution episcopic microscopy, HREM, diphtheria toxin fragment A, DTA, Biology (General), QH301-705.5 |
| الوصف: |
The embryonic process of forming a complex structure such as the heart remains poorly understood. Here, we show that Six2 marks a dynamic subset of second heart field progenitors. Six2-positive (Six2+) progenitors are rapidly recruited and assigned, and their descendants are allocated successively to regions of the heart from the right ventricle (RV) to the pulmonary trunk. Global ablation of Six2+ progenitors resulted in RV hypoplasia and pulmonary atresia. An early stage-specific ablation of a small subset of Six2+ progenitors did not cause any apparent structural defect at birth but rather resulted in adult-onset cardiac hypertrophy and dysfunction. Furthermore, Six2 expression depends in part on Shh signaling, and Shh deletion resulted in severe deficiency of Six2+ progenitors. Collectively, these findings unveil the chronological features of cardiogenesis, in which the mammalian heart is built sequentially by temporally distinct populations of cardiac progenitors, and provide insights into late-onset congenital heart disease. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211124717300207; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2017.01.002 |
| URL الوصول: |
https://doaj.org/article/a72167a7ecf54a7b8af0d6e59262520f |
| رقم الانضمام: |
edsdoj.72167a7ecf54a7b8af0d6e59262520f |
| قاعدة البيانات: |
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