Academic Journal
Association of the mthfr 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico
| العنوان: | Association of the mthfr 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico |
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| المؤلفون: | Leal-Ugarte Evelia, Peralta-Leal Valeria, Meza-Espinoza Pablo Juan, Durân-Gonzâlez Jorge, Macias-Gomez Nelly, Bocanegra-Alonso Anabel, Lara-Ramos José Ramon |
| المصدر: | Journal of Medical Biochemistry, Vol 38, Iss 4, Pp 461-467 (2019) |
| بيانات النشر: | Society of Medical Biochemists of Serbia, Belgrade, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biochemistry |
| مصطلحات موضوعية: | mthfr, 677c>t, obesity, overweight, biochemical variables, Biochemistry, QD415-436 |
| الوصف: | Background: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the MTHFR 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico. Methods: A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with overweight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for MTHFR 677C>T polymorphism was performed by the PCR-RFLP method. Results: There was no difference in the distribution of the MTHFR 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the T T genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes. Conclusions: These results suggest that the MTHFR 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further largescale population-based studies are still necessary to clarify the role of the MTHFR 677C>T polymorphism in overweight, obesity, and lipid profile level. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1452-8258 1452-8266 |
| Relation: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581904461L.pdf; https://doaj.org/toc/1452-8258; https://doaj.org/toc/1452-8266 |
| URL الوصول: | https://doaj.org/article/e7205e41a4c24bd09d80b799941080e6 |
| رقم الانضمام: | edsdoj.7205e41a4c24bd09d80b799941080e6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14528258 14528266 |
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