Academic Journal
Clinical and laboratory characteristics of Brazilian versus non-Brazilian primary antiphospholipid syndrome patients in AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) clinical database and repository
| العنوان: | Clinical and laboratory characteristics of Brazilian versus non-Brazilian primary antiphospholipid syndrome patients in AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) clinical database and repository |
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| المؤلفون: | Erivelton de Azevedo Lopes, Gustavo Guimarães Moreira Balbi, Maria G. Tektonidou, Vittorio Pengo, Savino Sciascia, Amaia Ugarte, H. Michael Belmont, Maria Gerosa, Paul R. Fortin, Chary Lopez-Pedrera, Lanlan Ji, Hannah Cohen, Guilherme Ramires de Jesús, D. Ware Branch, Cecilia Nalli, Michelle Petri, Esther Rodriguez, Nina Kello, Roberto Ríos-Garcés, Jason S. Knight, Tatsuya Atsumi, Rohan Willis, Maria Laura Bertolaccini, Doruk Erkan, Danieli Andrade, APS ACTION |
| المصدر: | Advances in Rheumatology, Vol 61, Iss 1, Pp 1-6 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the musculoskeletal system LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | Antiphospholipid syndrome, Primary antiphospholipid syndrome, Antiphospholipid antibodies, Lupus Anticoagulant, Anticardiolipin antibodies, Anti-beta-2 glycoprotein I antibodies, Diseases of the musculoskeletal system, RC925-935, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Abstract Background Antiphospholipid syndrome (APS) is characterized by episodes of thrombosis, obstetric morbidity or both, associated with persistently positive antiphospholipid antibodies (aPL). Studying the profile of a rare disease in an admixed population is important as it can provide new insights for understanding an autoimmune disease. In this sense of miscegenation, Brazil is characterized by one of the most heterogeneous populations in the world, which is the result of five centuries of interethnic crosses of people from three continents. The objective of this study was to compare the clinical and laboratory characteristics of Brazilian vs. non-Brazilian primary antiphospholipid syndrome (PAPS) patients. Methods We classified PAPS patients into 2 groups: Brazilian PAPS patients (BPAPS) and PAPS patients from other countries (non-BPAPS). They were compared regarding demographic characteristics, criteria and non-criteria APS manifestations, antiphospholipid antibody (aPL) profile, and the adjusted Global Antiphospholipid Syndrome Score (aGAPSS). Results We included 415 PAPS patients (88 [21%] BPAPS and 327 [79%] non-BPAPS). Brazilian patients were significantly younger, more frequently female, sedentary, obese, non-white, and had a higher frequency of livedo (25% vs. 10%, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2523-3106 |
| Relation: | https://doaj.org/toc/2523-3106 |
| DOI: | 10.1186/s42358-021-00222-3 |
| URL الوصول: | https://doaj.org/article/715cecf8601841039c95b619557f5261 |
| رقم الانضمام: | edsdoj.715cecf8601841039c95b619557f5261 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 25233106 |
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| DOI: | 10.1186/s42358-021-00222-3 |