Academic Journal
Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility
| العنوان: | Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility |
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| المؤلفون: | Sara Cipolat, Esther Hoste, Ken Natsuga, Sven R Quist, Fiona M Watt |
| المصدر: | eLife, Vol 3 (2014) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | skin, eczema, cancer, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Atopic dermatitis can result from loss of structural proteins in the outermost epidermal layers, leading to a defective epidermal barrier. To test whether this influences tumour formation, we chemically induced tumours in EPI−/− mice, which lack three barrier proteins—Envoplakin, Periplakin, and Involucrin. EPI−/− mice were highly resistant to developing benign tumours when treated with 7,12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). The DMBA response was normal, but EPI−/− skin exhibited an exaggerated atopic response to TPA, characterised by abnormal epidermal differentiation, a complex immune infiltrate and elevated serum thymic stromal lymphopoietin (TSLP). The exacerbated TPA response could be normalised by blocking TSLP or the immunoreceptor NKG2D but not CD4+ T cells. We conclude that atopy is protective against skin cancer in our experimental model and that the mechanism involves keratinocytes communicating with cells of the immune system via signalling elements that normally protect against environmental assaults. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/01888; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.01888 |
| URL الوصول: | https://doaj.org/article/7127dd80ee864c258ae99f7d7c316752 |
| رقم الانضمام: | edsdoj.7127dd80ee864c258ae99f7d7c316752 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.01888 |