التفاصيل البيبلوغرافية
| العنوان: |
Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes |
| المؤلفون: |
Peng Zhang, Jiali Fang, Guanghui Li, Lei Zhang, Xingqiang Lai, Lu Xu, Luhao Liu, Yunyi Xiong, Li Li, Tao Zhang, Jiao Wan, Hailin Xu, Rongxin Chen, Weiting Zhang, Junjie Ma, Zheng Chen |
| المصدر: |
Frontiers in Microbiology, Vol 12 (2021) |
| بيانات النشر: |
Frontiers Media S.A., 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
end-stage renal disease, IgA nephropathy, type-2 diabetes mellitus, gut microbiota, clinical immune indicators, chronic kidney disease, Microbiology, QR1-502 |
| الوصف: |
This study investigated the sex-specific differences in the correlation between intestinal microbiota and end-stage renal disease. Here, we compared the differences in the gut microbiota of male and female healthy controls (HC) and patients with end-stage renal disease (ESRD) caused by immunoglobulin A (IgA) nephropathy (ESRD-IgAN) or type-2 diabetes mellitus (ESRD-T2DM) using high-throughput sequencing of the 16S rRNA gene. We also analyzed the correlation between gut microbiota and clinical immune indicators. We assigned 8, 10, 5, 7, 11, and 20 volunteers to female HC, ESRD-IgAN, and ESRD-T2DM, and male HC, ESRD-IgAN, and ESRD-T2DM, respectively. The results showed sex-specific differences in both physiological and biochemical indices and intestinal microbiota composition, as well as the correlation between them. The correlations between physiological and biochemical indices in men were significantly lower than those in women, especially for indices related to immunity, blood glucose, and cardiac color sonography. Urine output, lymphocyte ratio, serum albumin, blood calcium, dialysis status, serum urea nitrogen, urine protein, and diabetes significantly correlated with male fecal microbiota composition, whereas only creatinine and 2-h post-prandial blood glucose significantly correlated with female fecal microbiota composition. The top 50 dominant operational taxonomic units showed a stronger correlation with physiological and biochemical indices in samples obtained from females than from males. These differences highlight sex-specific differences in the effectiveness of ESRD prevention and treatments via regulating intestinal microbiota. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-302X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmicb.2021.752393/full; https://doaj.org/toc/1664-302X |
| DOI: |
10.3389/fmicb.2021.752393 |
| URL الوصول: |
https://doaj.org/article/710942355da14d93bf3d49ef6e115694 |
| رقم الانضمام: |
edsdoj.710942355da14d93bf3d49ef6e115694 |
| قاعدة البيانات: |
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