Academic Journal
BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination
| العنوان: | BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination |
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| المؤلفون: | Xiu-Xiu Liu, Xing-Hui Chen, Zhi-Wei Zheng, Qin Jiang, Chen Li, Lin Yang, Xiang Chen, Xing-Feng Mao, Hao-Yang Yuan, Li-Li Feng, Quan Jiang, Wei-Xing Shi, Takuya Sasaki, Kohji Fukunaga, Zhong Chen, Feng Han, Ying-Mei Lu |
| المصدر: | Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-14 (2022) |
| بيانات النشر: | Nature Publishing Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Medicine, Biology (General), QH301-705.5 |
| الوصف: | Abstract Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific manipulations, we discovered a novel GABAergic Purkinje cell (PC) circuit in the cerebellar IV/V lobe that projected to CaMKIIα+ neurons in the fastigial nucleus (FN), which regulated sensorimotor coordination. Furthermore, transcriptomics profiling analysis revealed various cerebellar neuronal identities, and we validated that biorientation defective 1 (BOD1) played an important role in the circuit of IV/V lobe to FN. BOD1 deficit in PCs of IV/V lobe attenuated the excitability and spine density of PCs, accompany with ataxia behaviors. Instead, BOD1 enrichment in PCs of IV/V lobe reversed the hyperexcitability of CaMKIIα+ neurons in the FN and ameliorated ataxia behaviors in L7-Cre; BOD1 f/f mice. Together, these findings further suggest that specific regulation of the cerebellar IV/V lobePCs → FNCaMKIIα+ circuit might provide neuromodulatory targets for the treatment of ataxia behaviors. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2059-3635 |
| Relation: | https://doaj.org/toc/2059-3635 |
| DOI: | 10.1038/s41392-022-00989-x |
| URL الوصول: | https://doaj.org/article/7040bb88fa0149eea18a0a6f48fb8c9c |
| رقم الانضمام: | edsdoj.7040bb88fa0149eea18a0a6f48fb8c9c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20593635 |
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| DOI: | 10.1038/s41392-022-00989-x |