Academic Journal
Pharmacodynamic Effect of mTOR Inhibition-based Immunosuppressive Therapy on T- and B-cell Subsets After Renal Transplantation
| العنوان: | Pharmacodynamic Effect of mTOR Inhibition-based Immunosuppressive Therapy on T- and B-cell Subsets After Renal Transplantation |
|---|---|
| المؤلفون: | Xinyi Wei, MSc, Sabine Weber, MD, Decheng Yin, MSc, Ida Allabauer, Tilman Jobst-Schwan, MD, Michael Wiesener, MD, Mario Schiffer, MD, Diana Dudziak, PhD, Christian H. K. Lehmann, PhD, Joachim Woelfle, MD, Andre Hoerning, MD |
| المصدر: | Transplantation Direct, Vol 10, Iss 7, p e1666 (2024) |
| بيانات النشر: | Wolters Kluwer, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Surgery |
| مصطلحات موضوعية: | Surgery, RD1-811 |
| الوصف: | Background. The mammalian target of rapamycin inhibitor (mTORi) therapy after kidney transplantation is solely monitored pharmacokinetically, not necessarily reflecting PI3K-Akt-mTOR pathway blockade efficacy leading to potential under-or overimmunosuppression. Methods. In this cross-sectional study, phosphoflow cytometry was used to determine the efficacy of mTOR inhibition in peripheral T- and B-lymphocyte subsets by assessing p70S6 kinase (p70S6K) phosphorylation in renal transplant recipients upon treatment with a combination of either mTORi and calcineurin inhibitors (n = 18), or mTORi with mycophenolic acid (n = 9). Nine dialysis patients with end-stage renal disease and 17 healthy age-matched volunteers served as controls. Results. mTORi treatment reduced p70S6K phosphorylation in CD4+, CD8+ T, and CD19+ B cells compared with healthy controls (HCs). Subpopulation analysis of CD4+ T cells and CD19+ B cells revealed a significant reduction of p70S6K phosphorylation in CD4+CD45RA−CD25− Th cells (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2373-8731 00000000 |
| Relation: | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001666; https://doaj.org/toc/2373-8731 |
| DOI: | 10.1097/TXD.0000000000001666 |
| URL الوصول: | https://doaj.org/article/701e3fa629a94ad99b283dc1d0ebf8a1 |
| رقم الانضمام: | edsdoj.701e3fa629a94ad99b283dc1d0ebf8a1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23738731 00000000 |
|---|---|
| DOI: | 10.1097/TXD.0000000000001666 |