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Bioengineering of Extracellular Vesicles: Exosome-Based Next-Generation Therapeutic Strategy in Cancer

التفاصيل البيبلوغرافية
العنوان: Bioengineering of Extracellular Vesicles: Exosome-Based Next-Generation Therapeutic Strategy in Cancer
المؤلفون: Priyanka Saha, Suchisnigdha Datta, Sukanya Ghosh, Anurima Samanta, Paramita Ghosh, Dona Sinha
المصدر: Bioengineering, Vol 8, Iss 10, p 139 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Technology
LCC:Biology (General)
مصطلحات موضوعية: exosome, bioengineering, immunotherapy, exosomal cargo delivery, recombinant proteins, ncRNA, Technology, Biology (General), QH301-705.5
الوصف: Extracellular nano vesicles and exosomes hold compelling evidence in intercellular communication. Exosomal intracellular signal transduction is mediated by the transfer of cargo proteins, lipids, micro (mi)RNAs, long noncoding (lnc)RNAs, small interfering (si)RNAs, DNA, and other functional molecules that play a pivotal role in regulating tumor growth and metastasis. However, emerging research trends indicate that exosomes may be used as a promising tool in anticancer treatment. This review features a majority of the bioengineering applications of fabricated exosomal cargoes. It also encompasses how the manipulation and delivery of specific cargoes—noncoding RNAs (ncRNAs), recombinant proteins, immune-modulators, chemotherapeutic drugs, and other small molecules—may serve as a precise therapeutic approach in cancer management.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2306-5354
Relation: https://www.mdpi.com/2306-5354/8/10/139; https://doaj.org/toc/2306-5354
DOI: 10.3390/bioengineering8100139
URL الوصول: https://doaj.org/article/6fbaf85a24e84978bc99c0f27b815710
رقم الانضمام: edsdoj.6fbaf85a24e84978bc99c0f27b815710
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23065354
DOI:10.3390/bioengineering8100139