Academic Journal
Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites
| العنوان: | Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals living in sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparum merozoites |
|---|---|
| المؤلفون: | Abdou Khadre Dit Jadir Fall, Ikhlaq Hussain Kana, Asier Garcia-Senosiain, Benoît Henry, Célia Dechavanne, André Garcia, Pierre Buffet, Audrey Sabbagh, Florence Migot-Nabias, Michael Theisen, David Courtin |
| المصدر: | Heliyon, Vol 9, Iss 1, Pp e13092- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Opsonic phagocytosis, Fulani, Malaria resistance, Benin, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Objectives: Fulani in Africa are known to be less susceptible to Plasmodium falciparum (Pf) malaria. This study explored a potential involvement of antibody-mediated merozoite phagocytosis mechanism in this natural protection against malaria. Methods: Before the start of the malaria transmission season (MTS) in Benin, the functionality of antibodies against Pf merozoites was determined by the opsonic phagocytosis (OP) assay in plasma samples from Fulani, Bariba, Otamari and Gando groups. These individuals were actively followed-up for malaria detection from the beginning to the end of MTS. Anti-GLURP Immunoglobulin G antibody quantification, malaria Rapid Diagnostic Test (RDT) and spleen palpation were performed before and after MTS. Results: In Bariba, Otamari and Gando, but not in Fulani, plasma from adults promoted higher levels of OP than the children (P = 0.003; P = 0.012; P = 0.031 and P = 0.122). A high proportion of Fulani children had higher OP and anti-GLURP (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023002992; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e13092 |
| URL الوصول: | https://doaj.org/article/6f739912c5b7405a82c71dd44d57296a |
| رقم الانضمام: | edsdoj.6f739912c5b7405a82c71dd44d57296a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
|---|---|
| DOI: | 10.1016/j.heliyon.2023.e13092 |