Academic Journal
Curcumin: recent updates on gastrointestinal cancers
| العنوان: | Curcumin: recent updates on gastrointestinal cancers |
|---|---|
| المؤلفون: | Muhammad Imran, Farhan Saeed, Suliman A. Alsagaby, Ali Imran, Ishtiaque Ahmad, Ahmad H. El Ghorab, Mohamed A. Abdelgawad, Tahira Batool Qaisrani, Tahir Mehmood, Maryam Umar, Muhammad Arslan Mumtaz, Arfaa Sajid, Qaisar Manzoor, Muzzamal Hussain, Waleed Al Abdulmonem, Entessar Al Jbawi |
| المصدر: | CyTA - Journal of Food, Vol 21, Iss 1, Pp 502-513 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Food processing and manufacture |
| مصطلحات موضوعية: | Curcumin, gastrointestinal cancer, anti-cancer role, colon cancer, pancreatic cancer, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456 |
| الوصف: | ABSTRACTCurcumin is a phenolic pigment, naturally present in Curcuma longa species. It is a yellow active ingredient and shows a pivotal role in the modulation of biological processes resulting in the prevention of cancer particularly due to its radical scavenging activities. In gastrointestinal cancer cells, curcumin has been shown to induce cell death through apoptosis and to cause cell cycle arrest, down-regulating glycolytic enzyme expressions alongside inhibition of the matrix metalloproteinase-2 (MMP-2) promoter activity and SDF-1α-induced cell invasion. It also activates the expression of cleaved caspase-3, reduces cell viability, regulates the ratio of Bcl-2/Bax, decreases the number of cells in the proliferative G0/G1 phase and increases the number of cells in the S phase. Additionally, curcumin prevents DNA from replication during the S phase. This review discusses the chemo-preventive role of curcumin and its mechanisms against human gastrointestinal cancers to understand its activity and potential utilization as a therapeutic moiety. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian |
| تدمد: | 19476337 1947-6345 1947-6337 |
| Relation: | https://doaj.org/toc/1947-6337; https://doaj.org/toc/1947-6345 |
| DOI: | 10.1080/19476337.2023.2245009 |
| URL الوصول: | https://doaj.org/article/6f6c6b5f3e2948a5b0dfd84b817fee59 |
| رقم الانضمام: | edsdoj.6f6c6b5f3e2948a5b0dfd84b817fee59 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 19476337 19476345 |
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| DOI: | 10.1080/19476337.2023.2245009 |