التفاصيل البيبلوغرافية
| العنوان: |
Case Report: Repeated Low-Dose Rituximab Treatment Is Effective in Relapsing Neuro Behçet's Disease |
| المؤلفون: |
Chao Zhao, Chuan Li, Feng-ju Duan, Qi Yan, Zhuo Zhang, Ying Du, Wei Zhang |
| المصدر: |
Frontiers in Neurology, Vol 12 (2021) |
| بيانات النشر: |
Frontiers Media S.A., 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: |
neuro Behçet disease, treatment, rituximab, low dose, remission, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: |
Neuro Behçet's disease (NBD) is a rare but most aggressive manifestation of Behçet's disease (BD) with a poor prognosis, and some patients even present a relapsing and treatment-resistant progressive course. In some relapsing NBD cases, traditional corticosteroids and immunosuppressive drugs show limited efficacy, while benefits of biological agents, such as anti-B-lymphocyte CD20 biological agent rituximab (RTX), gradually represent potential therapeutic advantages with clinical rapid remission and long-time maintenance. However, up to now, the optimal dosage of RTX in NBD is still elucidated. Here, we report two patients with relapsing NBD, despite continuous high dose steroids and sufficient azathioprine treatment, still presenting severe and relapsing meningoencephalitis or brainstem involvement. Repeated low-dose RTX (100 mg × 3/1 week apart, 100 mg repeated every 6 months) is then attempted with rapid recovery and sustained remission. The approach in our cases may expand therapeutic options and provide helpful references for relapsing NBD treatment. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-2295 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fneur.2021.595984/full; https://doaj.org/toc/1664-2295 |
| DOI: |
10.3389/fneur.2021.595984 |
| URL الوصول: |
https://doaj.org/article/6f097be99c254f48874618d58216aa1f |
| رقم الانضمام: |
edsdoj.6f097be99c254f48874618d58216aa1f |
| قاعدة البيانات: |
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