التفاصيل البيبلوغرافية
| العنوان: |
Antibacterial compounds against fish pathogenic bacteria from a combined extract of Angelica gigas and Artemisia iwayomogi and their quantitative analyses |
| المؤلفون: |
Jae-Woong Lim, Na Young Kim, Jung-Soo Seo, Sung-Hee Jung, So Young Kang |
| المصدر: |
Fisheries and Aquatic Sciences, Vol 24, Iss 10, Pp 319-329 (2021) |
| بيانات النشر: |
The Korean Society of Fisheries and Aquatic Science, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Aquaculture. Fisheries. Angling |
| مصطلحات موضوعية: |
angelica gigas, artemisia iwayomogi, decursinol angelate, decursin, fish pathogenic bacteria, Aquaculture. Fisheries. Angling, SH1-691 |
| الوصف: |
In the search for antibiotic alternatives from safe and effective medicinal plants against fish pathogenic bacteria, we found that a combined extract (CE) of 1:1 (w/w) ratio of Angelica gigas Nakai roots and aerial parts of Artemisia iwayomogi Kitamura showed antibacterial activity against the fish pathogenic bacteria. By antibacterial activity-guided fractionations and isolations, five com-pounds were isolated and identified as decursinol angelate (1), decursin (2), xanthotoxin (3), demethylsuberosin (4), and 2,4-di-hydroxy-6-methoxyacetophenone (5) through spectroscopic analyses, such as nuclear magnetic resonance (NMR) and mass spectrometry (MS). Among the compounds, 1 and 2 showed the highest antibacterial activities against Streptococcus iniae and Vibrio anguillarum, showing minimum inhibitory concentrations (MICs) of 62.5–250 μg/mL. Compounds 3, 4, and 5 were also found to be active, with MICs of 31.25–1,000 μg/mL for those strains. Furthermore, active compounds, 1 and 2 in CE were simul-taneously quantified using high-performance liquid chromatography-tandem MS (HPLC-MS/MS). The average contents of 1 and 2 in CE was 3.68% and 6.14%, respectively. The established method showed reliable linearity (r2 > 0.99), good precision, accuracy, and specificity with intra- and inter-day variations of < 2 % and recoveries of 90.13%–108.57%. These results may be helpful for establishing the chemical profile of CE for its commercialization as an antibiotic alternative in aquaculture. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2234-1757 |
| Relation: |
http://www.e-fas.org/archive/view_article?pid=fas-24-10-319; https://doaj.org/toc/2234-1757 |
| DOI: |
10.47853/FAS.2021.e31 |
| URL الوصول: |
https://doaj.org/article/6e6719dbc05141f382c50753dab015fd |
| رقم الانضمام: |
edsdoj.6e6719dbc05141f382c50753dab015fd |
| قاعدة البيانات: |
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