Academic Journal
أعرض في EDS

The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells

التفاصيل البيبلوغرافية
العنوان: The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
المؤلفون: Farhad Seif, Majid Khoshmirsafa, Hossein Aazami, Monireh Mohsenzadegan, Gholamreza Sedighi, Mohammadali Bahar
المصدر: Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-13 (2017)
بيانات النشر: BMC, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Cytology
مصطلحات موضوعية: Medicine, Cytology, QH573-671
الوصف: Abstract The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarization of T helper cells. This pathway is regulated by an array of regulator proteins, including Suppressors of Cytokine Signaling (SOCS), Protein Inhibitors of Activated STATs (PIAS) and Protein Tyrosine Phosphatases (PTPs) determining the initiation, duration and termination of the signaling cascades. Dysregulation of the JAK-STAT pathway in T helper cells may result in various immune disorders. In this review, we represent how the JAK-STAT pathway is generally regulated and then in Th cell subsets in more detail. Finally, we introduce novel targeted strategies as promising therapeutic approaches in the treatment of immune disorders. Studies are ongoing for identifying the other regulators of the JAK-STAT pathway and designing innovative therapeutic strategies. Therefore, further investigation is needed.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1478-811X
Relation: http://link.springer.com/article/10.1186/s12964-017-0177-y; https://doaj.org/toc/1478-811X
DOI: 10.1186/s12964-017-0177-y
URL الوصول: https://doaj.org/article/6d777c91e91544b495bd61fa574b14ec
رقم الانضمام: edsdoj.6d777c91e91544b495bd61fa574b14ec
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1478811X
DOI:10.1186/s12964-017-0177-y