Academic Journal
Dexamethasone reduces cell surface levels of CD11b on human eosinophils
| العنوان: | Dexamethasone reduces cell surface levels of CD11b on human eosinophils |
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| المؤلفون: | A. M. Das, L. H. K. Lim, R. J. Flower, M. Perretti |
| المصدر: | Mediators of Inflammation, Vol 6, Iss 5-6, Pp 363-367 (1997) |
| بيانات النشر: | Wiley, 1997. |
| سنة النشر: | 1997 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | Pathology, RB1-214 |
| الوصف: | Overnight incubation of human eosinophils (Eøs) with the glucocorticoid hormone dexamethasone (DEX; 0.1 μM) resulted in lower expression of the CD11b, but not CD49d, antigen on their plasma membrane, as assessed by flow cytometry. DEX produced a consistent inhibitory effect (ranging from 16% to 20%) when tested at a concentration of 0.1 μM. Eø stimulation with 100 ng/ml eotaxin produced an increase in CD11b (+26%), but not CD11c, levels and concomitantly a reduction (–25%) on CD62L expression. The inhibition exerted by DEX upon CD11b levels was also evident following eotaxin upregulation, with a degree of inhibition similar to that seen on basal levels. These data highlight a novel mechanism of action by which glucocorticoid hormones may be effective in reducing Eø accumulation during allergic inflammation in man. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0962-9351 1466-1861 |
| Relation: | https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861 |
| DOI: | 10.1080/09629359791505 |
| URL الوصول: | https://doaj.org/article/6d6d7f7d204c449e90721178145e9009 |
| رقم الانضمام: | edsdoj.6d6d7f7d204c449e90721178145e9009 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09629351 14661861 |
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| DOI: | 10.1080/09629359791505 |