ABO Blood Groups and Thrombophilia Markers in Patients With Unstimulated Thrombosis in Kurdistan Region of Iraq

التفاصيل البيبلوغرافية
العنوان:	ABO Blood Groups and Thrombophilia Markers in Patients With Unstimulated Thrombosis in Kurdistan Region of Iraq
المؤلفون:	Ali Ibrahim Mohammed MD, FICMS, Aveen M. Raouf Abdulqader MD, PhD, Sana Dlawar Jalal MD, FICMS, Sarwar Noori Mahmood MD, FICMS, FEBU
المصدر:	Clinical and Applied Thrombosis/Hemostasis, Vol 26 (2020)
بيانات النشر:	SAGE Publishing, 2020.
سنة النشر:	2020
المجموعة:	LCC:Diseases of the circulatory (Cardiovascular) system
مصطلحات موضوعية:	Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف:	Thromboembolism (TE) is a complex disease caused by various acquired and inherited factors. The common mutations; factor V Leiden G1691A (FVL G1691A), prothrombin G20210A (PTG20210A), and methylene tetrahydrofolate reductase C677T (MTHFR C677T) are important inherited causes in both venous and arterial thrombosis. The association between ABO blood groups and thrombophilia has been noted by researchers. We aimed to determine the frequency and association of ABO blood groups as a risk factor along with 3 thrombophilia mutations and another 3 thrombophilia markers in a group of patients with unstimulated thrombosis. In a prospective case-control study, we focused on 100 samples, 50 patients with documented thrombosis as well as 50 healthy age-matched controls. Multiplex polymerase chain reaction and reverse hybridization to oligonucleotide particular probes were employed to detect FVL G1691A, PT G20210A, and MTHFR C677T mutations. Analysis of other thrombophilia markers including protein C (PC), protein S (PS), and antithrombin (AT) assays was also performed. ABO blood group typing was done according to standard methods. Non-O blood group was significantly more frequent among cases than controls (76% vs 54%) with high odds of TE (odds ratio [OR] = 2.69). Positivity for at least 1 thrombophilia marker was more in cases (60%) than controls (34%; OR = 2.9). The combined effect of non-O blood group and thrombophilia markers raised the risk of TE (OR = 4.16, P = .001), particularly FVL (OR = 6.76). This study illustrates that harboring the non-O blood group poses an additive effect with other thrombophilia markers in the causation of TE.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	1938-2723 10760296
Relation:	https://doaj.org/toc/1938-2723
DOI:	10.1177/1076029620922913
URL الوصول:	https://doaj.org/article/a6cec175c64541a1ac9874548a6cb317
رقم الانضمام:	edsdoj.6cec175c64541a1ac9874548a6cb317
قاعدة البيانات:	Directory of Open Access Journals

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الوصف
تدمد:	19382723 10760296
DOI:	10.1177/1076029620922913