التفاصيل البيبلوغرافية
| العنوان: |
Spill-Over from Public Health? First Detection of an OXA-48-Producing Escherichia coli in a German Pig Farm |
| المؤلفون: |
Alexandra Irrgang, Natalie Pauly, Bernd-Alois Tenhagen, Mirjam Grobbel, Annemarie Kaesbohrer, Jens A. Hammerl |
| المصدر: |
Microorganisms, Vol 8, Iss 6, p 855 (2020) |
| بيانات النشر: |
MDPI AG, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
OXA-48, CPE, carbapenemase, food chain, Biology (General), QH301-705.5 |
| الوصف: |
Resistance to carbapenems is a severe threat to human health. These last resort antimicrobials are indispensable for the treatment of severe human infections with multidrug-resistant Gram-negative bacteria. In accordance with their increasing medical impact, carbapenemase-producing Enterobacteriaceae (CPE) might be disseminated from colonized humans to non-human reservoirs (i.e., environment, animals, food). In Germany, the occurrence of CPE in livestock and food has been systematically monitored since 2016. In the 2019 monitoring, an OXA-48-producing E. coli (19-AB01443) was recovered from a fecal sample of a fattening pig. Phenotypic resistance was confirmed by broth microdilution and further characterized by PFGE, conjugation, and combined short-/long-read whole genome sequencing. This is the first detection of this resistance determinant in samples from German meat production. Molecular characterization and whole-genome sequencing revealed that the blaOXA-48 gene was located on a common pOXA-48 plasmid-prototype. This plasmid-type seems to be globally distributed among various bacterial species, but it was frequently associated with clinical Klebsiella spp. isolates. Currently, the route of introduction of this plasmid/isolate combination into the German pig production is unknown. We speculate that due to its strong correlation with human isolates a transmission from humans to livestock has occurred. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-2607 |
| Relation: |
https://www.mdpi.com/2076-2607/8/6/855; https://doaj.org/toc/2076-2607 |
| DOI: |
10.3390/microorganisms8060855 |
| URL الوصول: |
https://doaj.org/article/ea6c63d84e354c81a82b057692b5c843 |
| رقم الانضمام: |
edsdoj.6c63d84e354c81a82b057692b5c843 |
| قاعدة البيانات: |
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