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Evaluating Predictors of Quality in Liver NK Cells Among Deceased Donors

التفاصيل البيبلوغرافية
العنوان: Evaluating Predictors of Quality in Liver NK Cells Among Deceased Donors
المؤلفون: Yuki Imaoka, Masahiro Ohira, Toshihiro Nakayama, Miho Akabane, Tetsuya Tajima, Shinichiro Yokota, Sheri M. Krams, Olivia M. Martinez, Carlos O. Esquivel, Kazunari Sasaki, Hideki Ohdan
المصدر: Cell Transplantation, Vol 33 (2024)
بيانات النشر: SAGE Publishing, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
مصطلحات موضوعية: Medicine
الوصف: This study investigated the substantial variability in the quality of liver natural killer (NK) cells from deceased donors (DDs). This study assessed liver nonparenchymal cells from 51 DDs for activation receptors and cytotoxicity against K562 (leukemia) and HepG2 (hepatoma) cell lines. The results indicated variability in TNF-related apoptosis-inducing ligand (TRAIL) and NK stimulatory receptor NK group 2 member D (NKG2D) expression in liver NK cells from DDs, which correlated with cytotoxicity against tumor cell lines. In addition, the white blood cell (WBC) count, aspartate aminotransferase (AST) level, body mass index (BMI), and platelet count were significantly associated with enhanced TRAIL and NKG2D expression. A predictive score integrating AST/platelet ratio index, BMI, and WBC count was developed to effectively identify DDs with high antitumor activity in liver NK cells. This score is expected to predict DDs with high-quality liver NK cells, which can be used for the purpose of immunotherapies.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1555-3892
09636897
Relation: https://doaj.org/toc/1555-3892
DOI: 10.1177/09636897241283289
URL الوصول: https://doaj.org/article/6ba858aed22f4123ba7910b5a06719e0
رقم الانضمام: edsdoj.6ba858aed22f4123ba7910b5a06719e0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15553892
09636897
DOI:10.1177/09636897241283289