التفاصيل البيبلوغرافية
| العنوان: |
The Impact of Mediterranean Dietary Intervention on Metabolic and Hormonal Parameters According to BRCA1/2 Variant Type |
| المؤلفون: |
Andreina Oliverio, Paolo Radice, Mara Colombo, Angelo Paradiso, Stefania Tommasi, Antonella Daniele, Daniela Andreina Terribile, Stefano Magno, Donatella Guarino, Siranoush Manoukian, Bernard Peissel, Eleonora Bruno, Patrizia Pasanisi |
| المصدر: |
Frontiers in Genetics, Vol 13 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Genetics |
| مصطلحات موضوعية: |
BRCA1/2 genes, pathogenic variants, insulin, dietary intervention, metabolism, Genetics, QH426-470 |
| الوصف: |
The female carriers of BRCA1/2 pathogenic variants (mutations) face a high lifetime risk of developing breast and/or ovarian cancer. However, the risk may differ depending on various genetic and non-genetic elements, including metabolic and hormonal factors. We previously showed that a 6-month Mediterranean dietary intervention trial reduced body weight and the levels of insulin-like growth factor I and other metabolic factors in BRCA mutation carriers. We also found that higher baseline levels of glucose and insulin were significantly associated with BRCA loss-of-function (LOF) variants. In this study, we evaluated whether the BRCA mutation type influences in a different way the metabolic and hormonal response to the dietary intervention in 366 female carriers. The LOF variant carriers randomized in the intervention group (IG) showed significantly higher changes in most considered parameters compared to the control group (CG). The nonsynonymous variant carriers in the IG showed similar changes, but none of them were statistically significant. Performing the “delta” analysis of differences (intention-to-treat analysis), we observed that in LOF variant carriers, the reduction of insulin levels was significantly more pronounced that in nonsynonymous variant carriers. These findings suggest that the changes in insulin levels might be modulated by a different response to the dietary intervention mediated by BRCA LOF variants. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-8021 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fgene.2022.820878/full; https://doaj.org/toc/1664-8021 |
| DOI: |
10.3389/fgene.2022.820878 |
| URL الوصول: |
https://doaj.org/article/6b7f272113cf49349aa61b307a767449 |
| رقم الانضمام: |
edsdoj.6b7f272113cf49349aa61b307a767449 |
| قاعدة البيانات: |
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